Transforming Growth Factor beta2 Receptor (16CT) (TGFb2R , TGFBR2, Transforming growth factor, beta receptor II, AAT3, FAA3, HNPCC6, LDS1B, LDS2B, MFS2, RIIC, TAAD2, TbetaR-II, TGFbeta-RII)

TGF-B is a multifunctional polypeptide growth factor. While specific receptors for this protein have been found on almost all mammalian cell types, the effect of the molecule varies depending on the cell type and growth conditions. Generally, TGF-B is stimulatory for cells of mesenchymal origin and inhibitory for cells of epithelial or neuroectodermal origin. It is a family of regulatory proteins consisting of a number of proteins distantly related. TGF-B1 has been found in the highest concentration in human platelets and mammalian bone, but is produced by many cell types in smaller amounts. TGF-B2 has been found in the highest concentration in porcine platelets and mammalian bone, but again is also produced by many types of cells. The heterodimer, TGF-B1.2, has so far been found only in small amounts in porcine platelets. TGF-B3 has been detected in human, porcine, and avian sources, mainly in cells of mesenchymal origin, suggesting a different role for this protein than for TGF-B1 or TGF-B2. TGF-B4 has been detected so far only in chick embryo chondrocytes, and its distribution in other types of cells has not yet been characterized. TGF-B5 has been detected only in Xenopus embryos. TGF-B1, TGF-B2, and TGF-B1.2 appear to be largely equivalent in biological activity, although there appear to be differences in binding to certain types of receptors, and there are a few reports of differential responses to TGF-B1 and TGF-B2. Transforming Growth factor beta2 receptor is present at low abundance, ~200 receptors/cell.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested. \n\nRecommended Dilutions: \nWestern Blot: 1-5ug/ml will recognize p75 TGF-beta2 receptor from 10ug fresh MG63 osteosarcoma lysate, or 20ug freshly prepared TF-1 human erythroleukemia cell lysate.\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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