TRAP, Recombinant, Murine (CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L, CD40 ligand, CD40-L, Tumor necrosis factor liga

CD40 Ligand (CD40L/TRAP) is a type II transmembrane glycoprotein belonging to the TNF superfamily of ligands. Natually, CD40L is a membrane-bound protein, but proteolytically cleaved 15-18kD soluble forms of CD40L are also fully active. CD40L plays an important role in the proliferation and differentiation of B-cells, and is critical for immunoglobulin (Ig) class switching. Recombinant murine CD40 Ligand is a soluble 18kD protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CDE40L.\n\nSource:\nRecombinant protein corresponding to mouse CD40Ligand/TRAP, expressed in E. coli.\n\nMolecular Weight: \n~16.4kD\n\nBiological Activity:\nED50 is <0.1ug/ml determined by its ability to induce TNF-a and MIP-1a production by murine splenocytes.\n\nEndotoxin:\n<0.1ng/ug\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts