TRBP2 (Trans Activation Responsive RNA Binding Protein 2, Tar (HIV-1) RNA Binding Protein 2, TAR RNA-binding Protein 2, TARBP2, TRBP, LOQS, RISC-loading Complex Subunit TARBP2)

TRBP is an RNA associated nuclear protein. It contains 3 DRBM (double stranded RNA-binding) domains and plays an important role by binding to HIV-1 TAR RNA located in the long terminal repeat (LTR). TRBP acts synergistic with viral TAT protein in HIV-1 expression activation. It binds preferentially to TAR and other double-stranded RNAs with G+C-rich characteristics. It is important in regulation of transcription from RNA polymerase II promoter and is widely expressed in most of the tissues.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 5-8ug/ml\nImmunohistochemistry (paraffin): 5-10ug/ml\nOptimal dilutions to be determined by the researcher. \n\nPositive Control:\nHuman brain lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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