Home  >  Products  >  TRBP2 (Trans-activation Responsive RNA Binding Protein 2, Tar (HIV-1) RNA Binding Protein 2, TAR RNA-binding Protein 2, TARBP2, TRBP, LOQS, RISC-loading Complex Subunit TARBP2)
TRBP2 (Trans-activation Responsive RNA Binding Protein 2, Tar (HIV-1) RNA Binding Protein 2, TAR RNA-binding Protein 2, TARBP2, TRBP, LOQS, RISC-loading Complex Subunit TARBP2)

TRBP2 (Trans-activation Responsive RNA Binding Protein 2, Tar (HIV-1) RNA Binding Protein 2, TAR RNA-binding Protein 2, TARBP2, TRBP, LOQS, RISC-loading Complex Subunit TARBP2)

Cat no: T8269-01C

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8269-01C
Reactivities: Human, Mouse, Rat, Bovine, Zebrafish/Fish
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Trans-activation-responsive RNA-binding Protein
References: 1. Battisti,P.L., Daher,A., Bannwarth,S., Voortman,J., Peden,K.W., Hiscott,J., Mouland,A.J., Benarous,R. and Gatignol,A. Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells AIDS Res. Hum. Retroviruses 19 (9), 767-778 (2003) 2. Daher,A., Longuet,M., Dorin,D., Bois,F., Segeral,E., Bannwarth,S., Battisti,P.L., Purcell,D.F., Benarous,R., Vaquero,C., Meurs,E.F. and Gatignol,A. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression J. Biol. Chem. 276 (36), 33899-33905 (2001)
Additional info: Recognizes human TRBP2. Species Crossreactivity: bovine, chimpanzee, mouse, rat, zebrafish.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave