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TRC8 (Translocation in renal carcinoma on Chromosome 8, RNF139, ring finger protein 139, HRCA1, MGC31961, RCA1) (AP)

Cat no: T5890-01-AP

TRC8 (Translocation in renal carcinoma on Chromosome 8, RNF139, ring finger protein 139, HRCA1, MGC31961, RCA1) (AP)

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq]\n\nApplications:\nSuitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1,000\nImmunohistochemistry (paraffin): 1.5ug/ml\nELISA: 1ug/ml-3ng/ml \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5890-01-AP

Size

100ul

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human RNF139.

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