Home  >  Products  >  TRC8 (Translocation in renal carcinoma on Chromosome 8, RNF139, ring finger protein 139, HRCA1, MGC31961, RCA1)
TRC8 (Translocation in renal carcinoma on Chromosome 8, RNF139, ring finger protein 139, HRCA1, MGC31961, RCA1)

TRC8 (Translocation in renal carcinoma on Chromosome 8, RNF139, ring finger protein 139, HRCA1, MGC31961, RCA1)

Cat no: T5890

Supplier: United States Biological
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The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16000 Western Blot: 0.5-1.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T5890
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by antigen immunoaffinity chromatography.
References: 1. Gemmill RM, et al., The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9572-7. PMID: 9689122.
Additional info: Recognizes human TRC8 at ~150kD. Species sequence homology: canine.

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