The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa and functions as a gastric-specific tumor suppressor gene. Recombinant human TFF1 is a 6.7kD monomeric protein consisting of a 60aa polypeptide chain, which includes a 40aa trefoil motif containing three conserved intramolecular disulfide bonds.
Source:
Recombinant protein corresponding to human Trefoil Factor 1, expressed in E.coli.
Biological Activity:
Determined by its ability to chemoattract human MCF-7 cells using a concentration 5-10ug/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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