The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma. Recombinant human TFF2 is a 12kD polypeptide of 106aa, which includes a 40aa trefoil motif containing three conserved intramolecular disulfide bonds.
Source:
Recombinant protein corresponding to human Trefoil Factor 2, expressed in E.coli.
Biological Activity:
Assay #1: Biological activity was determined by its ability to chemoattract human monocytes using a concentration range of 1-10ug/ml.
Assay #2: Biological activity was determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1-10ng/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKS VEDCHY
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Quick Search
Products 
