The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation. Recombinant human TFF3 is a 13.2kD homodimeric protein consisting of two 59aa chains, which includes a 40aa trefoil motif containing three conserved intramolecular disulfide bonds.
Source:
Recombinant protein corresponding to human Trefoil Factor 3, expressed in E.coli.
Biological Activity:
Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1-10ug/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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