TREM-1 (Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1 precursor)

TREM-1 stimulates neutrophils and monocytes-mediated inflammatory responses. TREM-1 activation, together with LPS and other PRR ligands, amplifies the production pro-inflammatory cytokines and thus the inflammatory response. The TREM-1 pathway also plays a crucial role in septic shock. Clone has been shown to activate monocytes and granulocytes.\n\nApplications:\nSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nRecommended Secondary Antibodies:\nGoat Anti Mouse IgG IgA IgM Alk. Phos., HRP\nHuCAL Anti Mouse IgG2b FITC, HRP, RPE\nSheep Anti Mouse IgG (H&L) Biotin, FITC\nGoat Anti Mouse IgG (H&L) Alk. Phos., DyLight(TM)488, DyLight(TM)549, DyLight(TM)649, FITC, HRP\nRabbit Anti Mouse IgG RPE\nGoat Anti Mouse IgG (Fc) FITC, HRP\nRabbit Anti Mouse IgG HRP\nGoat Anti Mouse IgG ITC\nGoat Anti Mouse IgG RPE\nGoat Anti Mouse IgG HRP\nRabbit Anti Mouse IgG FITC\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8282-09

Size

25ug

Applications

FC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes Triggering receptor expressed on myeloid cells 1 (TREM-1), a receptor expressed on CD14+ monocytes, macrophages and neutrophils. It is also highly expressed in inflammatory lesions caused by fungi and bacteria. It stimulates neutrophil and monocyte-mediated inflammatory responses.