Mouse triggering receptor expressed on myeloid cells 1 (TREM-1), is a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
Applications:
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 1:25-1:100 10ul label 1x10e6 cells in 100ul.
Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies:
I1904-47H IgG, H&L (HRP) Pab GtxRt
I1904-47N IgG, H&L, X-Adsorbed (HRP) Pab GtxRt
I1904-74H IgG, Mouse Ig Adsorbed (HRP) Pab GtxRt
I1904-48S IgG, H&L (HRP) Pab RbxRt
I1904-48X IgG, H&L, X-Adsorbed (HRP) Pab RbxRt
I1904-50V1 IgG H&L, X-adsorbed (HRP) Pab RbxRt
Recommended Negative Control:
I1904-83V1: IgG2a Negative Control (Biotin)
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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