Triggering receptor expressed on myeloid cells 1 (TREM-1) is a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Functional applications. Not recommended for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions:
Flow cytometry: 1:25-1:100. Use 10ul of the suggested working dilution to label 10e6 cells in 100ul.
Optimal dilutions to be determined by the researcher.
Endotoxin: (same/less than)0.01EU/ug
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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