TREM-2 is a single Ig domain receptor expressed by cells of myeloid lineage. Two closely related transcripts were reported in mouse and designated TREM-2a and TREM-2b. TREM-2b is a pattern recognition receptor that binds anionic ligands. TREM-2 associates with the adapter protein DAP12 to deliver an activating signal that plays a role in both innate and adaptive immune responses.
Applications:
Suitable for use in Flow Cytometry, Direct ELISA and Western Blot. Other applications not tested.
Recommended Dilutions:
Flow Cytometry: 2.5ug/10e6 cells using RAW 264.7 mouse monocyte/macrophage cell line, THP-1 human acute monocytic leukemia cell line, and human mature dendritic cells
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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