Home  >  Products  >  TRIAD3A (Triad Domain-containing Protein 3, Triad3, E3 Ubiquitin-protein Ligase RNF216, RING Finger Protein 216, RNF216, U7I1, Ubiquitin-conjugating Enzyme 7-interacting Protein 1, Ubce7ip1, Zinc Finger Protein Inhibiting NF-kappa-B, ZIN)
TRIAD3A (Triad Domain-containing Protein 3, Triad3, E3 Ubiquitin-protein Ligase RNF216, RING Finger Protein 216, RNF216, U7I1, Ubiquitin-conjugating Enzyme 7-interacting Protein 1, Ubce7ip1, Zinc Finger Protein Inhibiting NF-kappa-B, ZIN)

TRIAD3A (Triad Domain-containing Protein 3, Triad3, E3 Ubiquitin-protein Ligase RNF216, RING Finger Protein 216, RNF216, U7I1, Ubiquitin-conjugating Enzyme 7-interacting Protein 1, Ubce7ip1, Zinc Finger Protein Inhibiting NF-kappa-B, ZIN)

Cat no: T8319-05E

Supplier: United States Biological
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TRIADs are novel zinc finger proteins characterized by the presence of Cysteine rich TRIAD domain consisting of DRIL motif flanked by 2 RING fingers. TRIAD3, a 56kD protein, is a novel member of this family. It contains 4 RLD domains in the centre and a proline-rich domain at the C-terminus. Localized in the cytoplasm, it interacts with RIP and inhibits TNF and IL1-induced NF-kappaB activation pathways. Reports suggest TRIAD3 acts as an E3-ubiquitin-protein ligase and promotes ubiquitination and degradation of TLR4 and TLR9, thereby regulating TLR signaling. It also interacts with HIV type I Vif protein and interferes in the early events of HIV-1 replication. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain, heart, kidney, liver, lung, ovary, pancreas, small intestine, skeletal muscle, spleen, or testes. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8319-05E
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
Alternative names: EC=6.3.2.-, UbcM4-interacting protein 83, Uip83,
References: 1. Accession number AY177398.1 2. Bert et.al. Protein Science, 8:1557
Additional info: Recognizes human TRIAD3A.

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