Home  >  Products  >  Triadin (TDN, TRDN, dJ166D18.1, DKFZp779I2253, MGC88285, OTTHUMP00000040354, TRISK, TRISK 51, TRISK51, TRISK-51)
Triadin (TDN, TRDN, dJ166D18.1, DKFZp779I2253, MGC88285, OTTHUMP00000040354, TRISK, TRISK 51, TRISK51, TRISK-51)

Triadin (TDN, TRDN, dJ166D18.1, DKFZp779I2253, MGC88285, OTTHUMP00000040354, TRISK, TRISK 51, TRISK51, TRISK-51)

Cat no: T8320-01

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR?s) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR?s), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95kD) transmits electrochemical signals to the SR through direct interaction with both DHPR?s and RyR?s. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae. Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8320-01
Reactivities: Mouse, Rabbit
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 100ul
Form: 0.05% Sodium Azide; PBS diluted Ascites
P type: Mab
Isotype: IgG1
Purity: Ascites
References: Campbell KP et al. Identification and characterization of the high affinity [3H]ryanodine receptor of the junctional sarcoplasmic reticulum Ca2+ release channel. J Biol Chem 262:6460-3 (1987). Leung AT et al. Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits. J Biol Chem 262:7943-6 (1987). Imagawa T et al. Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle. J Biol Chem 262:8333-9 (1987).
Additional info: This antibody does not detect triadin from cardiac tissues. Species Crossreactivity: Crossreacts with Mouse and Rabbit. Not yet tested in other species.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave