Home  >  Products  >  TRIB1 (Tribbles Homolog 1, TRB-1, SKIP1, G-protein-coupled Receptor-induced Protein 2, GIG-2, TRIB1, C8FW, GIG2)
TRIB1 (Tribbles Homolog 1, TRB-1, SKIP1, G-protein-coupled Receptor-induced Protein 2, GIG-2, TRIB1, C8FW, GIG2)

TRIB1 (Tribbles Homolog 1, TRB-1, SKIP1, G-protein-coupled Receptor-induced Protein 2, GIG-2, TRIB1, C8FW, GIG2)

Cat no: T8335-40E

Supplier: United States Biological
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TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8335-40E
Reactivities: Human, Mouse, Bovine
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE, Crossman DC, Kiss-Toth E. Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem. 2007 Jun 22;282(25):18379-87. Epub 2007 Apr 23.
Additional info: Recognizes TRIB1. Species sequence homology: Bovine, human and mouse.

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