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TRIB3 (TRB-3, tribbles homolog 3, Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK)

TRIB3 (TRB-3, tribbles homolog 3, Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK)

Cat no: T8340-80

Supplier: United States Biological
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Tribbles homolog 3 (Drosophila), TRIB3, is a putative protein kinase that has been implicated in the regulation of several biological processes in mammalian cells through its ability to influence Akt and other signaling pathways. It is an important negative regulator of adipogenesis because it acts at an early step in the differentiation cascade to block the C/EBPb proadipogenic function. TRB3 disrupts insulin signaling by binding directly to Akt and blocking activation of the kinase, thus contributing to insulin resistance in individuals with susceptibility to type II diabetes. TRIB3 expression is remarkably reduced in prostate cancer PC-3 cells after inhibition of phosphatidylinositol (PI) 3-kinase. The expression of TRIB3 is controlled by nutrient supplies, where the lack of glucose or amino acids results in a substantial increase in TRIB3 protein levels in a PI 3-kinase-dependent manner. (1-3). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: T8340-80
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: TRB-3, Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK
References: 1.Schwarzer R, et al. Cell Signal. 18(6):899-909, 2000 2.Bezy O, et al. Molecular and Cellular Biology 27(19):6818-6831, 20073.Du K, et al. Science 300(5625):1574
Additional info: Recognizes human TRIB3.

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