Home  >  Products  >  TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3)
TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3)

TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3)

Cat no: T8335-43J

Supplier: United States Biological
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A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8335-43J
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. J. Biol. Chem. 278 (29), 27072-27079 (2003) 2. Du,K., Herzig,S., Kulkarni,R.N. and Montminy,M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300 (5625), 1574-1577 (2003).
Additional info: Recognizes human TRIB3.

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