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Trichostatin A (TSA) (Histone Deacetylase Inhibitor)

Trichostatin A (TSA) (Histone Deacetylase Inhibitor)

Cat no: T8375-01

Supplier: United States Biological
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4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxohepta-2, 4-dienohydroxamic acid. Histone deacetylase inhibitor isolated from Streptomyces. Inhibition of Histone Deacetylation: As shown with a previous lot, incubation of A431 cells with 50-100ng/ml Trichostatin A for 24 hours inhibited deacetylation of histones in vivo, as detected using anti-acetyl Histone H4. The optimal concentration of Trichostatin A should be empirically determined for the type of cells and assay used.
Catalogue number: T8375-01
Size: 1mg
Form: Supplied as a powder.
Purity: > 98% by HPLC analysis.
References: 1. El-Osta, A., et al., Mol. Cell. Biol. 22: 1844-57, 2002. 2. Taunton, J., et al., Science 272: 408-411, 1996. 3. Yoshida, M. and T., Beppu, Exper. Cell Res. 177: 122-131 1988.

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