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SPECIFICATIONS
Price
323.00 USD
Catalog Number
CAC07790
Size
100 micro g
Applications
IF, IHC, WB
Hosts
Rabbit
Conjugates
Unconj
Purity
Protein G purified, >95%
Target
TRIM25
Clonality
Polyclonal
Storage Temp
Aliquot and store at -20 degrees C. Minimize freezing and thawing.
Research Area
For research use only. Not for diagnostic procedures.
Shipping Temp
Blue ice
Additional Info
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
Alternative Names
E3 ubiquitin/ISG15 ligase TRIM25,Estrogen-responsive finger protein,RING finger protein 147,RING-type E3 ubiquitin transferase (EC:2.3.2.271,TRIM25,EFP,RNF147,ZNF147
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