Home  >  Products  >  TRIM3 (Tripartite Motif-containing Protein 3, Brain-expressed RING Finger Protein, RING Finger Protein 22, RING Finger Protein 97, BERP, RNF22, RNF97)
TRIM3 (Tripartite Motif-containing Protein 3, Brain-expressed RING Finger Protein, RING Finger Protein 22, RING Finger Protein 97, BERP, RNF22, RNF97)

TRIM3 (Tripartite Motif-containing Protein 3, Brain-expressed RING Finger Protein, RING Finger Protein 22, RING Finger Protein 97, BERP, RNF22, RNF97)

Cat no: T8464-75E

Supplier: United States Biological
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.1-1ug/ml, mouse brain and human brain (cerebellum) observed on ~85kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8464-75E
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. El-Husseini AE, Fretier P, Vincent SR. Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. Genomics. 2001 Feb 1;71(3):363-7.
Additional info: Recognizes mouse BERP. Species sequence homology: Bovine, canine, human and rat.

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