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TRIP (TRAF Interacting Protein, TRAF-interacting Protein, TRAIP, RING Finger Protein 206, RNF206)

TRIP (TRAF Interacting Protein, TRAF-interacting Protein, TRAIP, RING Finger Protein 206, RNF206)

Cat no: T8495-03D

Supplier: United States Biological
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The TNF receptor-associated factor (TRAF) family is a group of cytoplasmic adapter proteins that link a wide variety of cell surface receptors including the TNF and IL-1 receptor (TRNFR and IL-1R) superfamily to diverse signaling cascades involved in differentiation, proliferation, activation and apoptosis. TRIP (TRAF-interacting protein) was identified in 1997 as a component of receptor-TRAF signaling complexes (Lee, 1997). TRIP (also known as TRAIP) has been shown to associate with TRNFR2 or CD30 signaling complexes through its interaction with TRAF proteins and inhibit TRAF2-mediated NF-kB activation (Lee, 1997; Regamey et al, 2003). The recruitment of different TRAFs and TRAF associated proteins like TRIP to receptor complexes can help regulate and provide specificity to the intracellular signals triggered by the cell surface receptors. Recognizes TRIP; human TRIP as a 469aa protein. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000 Immunoprecipitation: 1:50-1:200 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Spleen, lymphoid, CA cell lines Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8495-03D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Lee SY, SY Lee, and Y Choi. 1997. TRAF-interacting protein (TRIP): A novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kB activation. J Exp Med. 185:1275-1286. 2. Regamey A, D Hohl, JW Liu, T Roger, P Kogerman, R Toftgard and M Huber. 2003. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kB activation by tumor necrosis factor. J Exp Med. 198:1959-1964.
Additional info: Recognizes human TRIP.

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