Triptorelin Acetate

Triptorelin Acetate (Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) is a synthetic analogue of gonadorelin (GnRH). As a result of the substitution of the 6th amino acid residue in the native molecule, the agonistic effect is more pronounced and the plasma half-life prolonged. \n\nStorage and Stability:\nLyophilized powder is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8525

Size

5mg

Form

Supplied as a lyophilized powder. No additives. Reconstitute with sterile ddH2O to prepare a stock solution with concentration (same/more than)0.1mg/ml. Further dilutions can be made wtih buffer.

Purity

(same/more than) 98% by RP-HPLC. Chromatographically purified.

References

1. Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells. Grundker C, Gunthert AR, Emons G, Eur J Endocrinol 2004 Nov;151(5):619-28 2. An open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis. Wong AY, Tang L, Fertil Steril 2004 Jun;81(6):1522-7 3. Equivalence of the 3-month and 28-day formulations of triptorelin with regard to achievement and maintenance of medical castration in women with endometriosis. Donnez J, Dewart PJ, Perino A, Fertil Steril 2004 Feb;81(2):297-304 4. Triptorelin versus cetrorelix in intracytoplasmic sperm injection cycles in women with a single ovary. Nikolettos N, Asimakopoulos B, Al-Hasani S, Eur J Obstet Gynecol Reprod Biol 2004 Feb 10;112(2):185-8. 5. Alopecia in a premenopausal breast cancer woman treated with letrozole and triptorelin. Carlini P, Di Cosimo S, Papaldo P, Cognetti F, Ann Oncol 2003 Nov;14(11):1689-90 6. Comparative efficacy of triptorelin pamoate and leuprolide acetate in men with advanced prostate cancer. Heyns CF, Simonin MP, Schall R, BJU Int 2003 Aug;92(3):226-31.