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Trk-Fused Gene Protein (Protein TFG, TFG, FLJ36137, TF6, TRKT3)

Trk-Fused Gene Protein (Protein TFG, TFG, FLJ36137, TF6, TRKT3)

Cat no: T8662-80

Supplier: United States Biological
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TFG protein, a recently identified novel protein, is a human homolog of mouse TFG protein. It contains an N-terminal coiled-coil structure, a SPYGQ-rich region followed by octicosapeptide repeats. Research shows that TFG can modulate SHP-1 activity and is a novel member of the NF-kB pathway. The physiological functions of this protein remain largely elusive, but TFG is thought to function by associating with other proteins, including TANK and NEMO. TFG was first identified as a partner of NTRK1 and is involved in generating the thyroid TRK-T3 oncogene, as well as oncogenic rearrangements with ALK in anaplastic lymphoma and NOR1 in mixoid chondrosarcoma. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8662-80
Reactivities: Human, Mouse, Rat, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hisaoka, M. et al. Genes Chromosomes Cancer. 40:325-333 (2004). 2. Roccato, E. et al. J. Biol. Chem. 280:3382-3389 (2005). 3. Miranda, C. et al. J. Cell. Physiol. 208:154-160 (2006).
Additional info: Recognizes human Trk-Fused gene protein. Species Crossreactivity: chimpanzee, monkey, rat. Species sequence homology: mouse, canine, bovine, zebrafish, opossum.

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