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MtoZ Biolabs

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TrkA (6B2) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252878

TrkA (6B2) Antibody

TrkA is a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA e, Xenopus/Amphibian,ists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma.

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SPECIFICATIONS

Catalog Number

252878

Size

0.1 ml

Applications

IF

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cell line.

Isotype

Mouse IgG1

Accession

P04629

Clonality

6B2

Additional Info

High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK

SUPPLIER INFO

ABBIOTEC

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