TrkA (6B2) Antibody

Cat no: 252878

Supplier: ABBIOTEC

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Description
Additional Information

TrkA is a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA e, Xenopus/Amphibian,ists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma.

Catalogue number:	252878
Reactivities:	Human
Applications:	Immunofluorescence
Size:	0.1 ml
Accession:	P04629
Antigen:	Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cell line.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	6B2
Additional info:	High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK