TrkA Antibody

Cat no: 250893

Supplier: ABBIOTEC

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Description
Additional Information

The Trk family of nerve growth factor receptors includes TrkA, TrkB and TrkC. The prototype member of this gene family, TrkA encodes a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA e, Xenopus/Amphibian,ists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma.

Catalogue number:	250893
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P04629
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TrkA.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK