TrkB Antibody

Cat no: 250896

Supplier: ABBIOTEC

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Description
Additional Information

The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser e, Xenopus/Amphibian,tent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B (gp 145). Trk C, the third member of the Trk receptor family, encodes a 140-kDa protein, Trk C gp 140, that is preferentially e, Xenopus/Amphibian,pressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor comple, Xenopus/Amphibian,, NGFR p 175 , binds to neurotrophic factor with low affinity but is required for efficient signaling.

Catalogue number:	250896
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q16620
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Trk B.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB; TrkB tyrosine kinase; GP145-TrkB; Trk-B; GP145; NTRK2