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TrkCT1 (ETV6 NTRK3 fusion, GP145 TrkC, gp145(trkC), GP145TrkC, Neurotrophic tyrosine kinase receptor type 3, Ntrk3)

Cat no: 168566

TrkCT1 (ETV6 NTRK3 fusion, GP145 TrkC, gp145(trkC), GP145TrkC, Neurotrophic tyrosine kinase receptor type 3, Ntrk3)

TrkCT1, also named neurotrophic tyrosine kinase receptor type 3 (Ntrk3) non-catalytic isoform 2, is a non-catalytic isoform of TrkC, the high affinity receptor for Neurotrophin-3 (NT-3). This isoform lacks the kinase domain that is responsible for signaling by the full-length isoform. TrkCT1 is the product of an alternative splicing of Ntrk3 that leaves the extracellular and transmembrane domains intact but includes a shorter intracellular domain encoded by exons 13b and 14b. Recent studies indicate that the short cytoplasmic tail binds the scaffold protein Tamalin in a ligand-dependent manner and further activates the Arf6

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SPECIFICATIONS

Catalog Number

168566

Size

100ug

Applications

ELISA, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes mouse TrkCT1. Species Crossreactivity: human and rat.

Alternative Names

ETV6 NTRK3 fusion antibody, GP145 TrkC antibody, gp145(trkC) antibody, GP145TrkC antibody, Neurotrophic tyrosine kinase receptor type 3 antibody, Ntrk3 antibody

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