Home  >  Products  >  TROP2 (TROP-2, Tumor-associated Calcium Signal Transducer 2, Pancreatic Carcinoma Marker Protein GA733-1, Cell Surface Glycoprotein Trop-2, Membrane Component Chromosome 1 Surface Marker 1, M1S1, GA733-1, TACSTD2)
TROP2 (TROP-2, Tumor-associated Calcium Signal Transducer 2, Pancreatic Carcinoma Marker Protein GA733-1, Cell Surface Glycoprotein Trop-2, Membrane Component Chromosome 1 Surface Marker 1, M1S1, GA733-1, TACSTD2)

TROP2 (TROP-2, Tumor-associated Calcium Signal Transducer 2, Pancreatic Carcinoma Marker Protein GA733-1, Cell Surface Glycoprotein Trop-2, Membrane Component Chromosome 1 Surface Marker 1, M1S1, GA733-1, TACSTD2)

Cat no: T8663-95H

Supplier: United States Biological
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TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Western Blot: 0.2-0.5ug/ml, observed in human prostate lysates on ~37kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8663-95H
Reactivities: Human, Mouse, Rat, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Shimada A, Kano J, Ishiyama T, Okubo C, Iijima T, Morishita Y, Minami Y, Inadome Y, Shu Y, Sugita S, Takeuchi T, Noguchi M. Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development. Cancer Sci. 2005 Oct;96(10):668-75.
Additional info: Recognizes human TROP2. Species sequence homology: Bovine, canine, mouse, porcine and rat.

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