Supplier:
Alomone Labs Ltd.Cat no: T-120
Tropicamide
Muscarinic acetyl choline receptors (mAChR) regulate a number of important basic physiologic functions including heart rate, motor and sensory control and more complex behaviors including arousal, memory, and learning. Loss of muscarinic receptor number or function has been implicated in the etiology of several neurological disorders including Alzheimer's dementia, Down's syndrome and Parkinson's disease.
Five subtypes of muscarinic receptors (m1-m5) have been identified by molecular cloning and much has been learned about their distribution, pharmacology, and structure.
Tropicamide is a M4 selective muscarinic receptor antagonist, which shows a 3 fold selectivity for m4. Its effect has a pIC50 of ~7.5 for porcine intravesical ureter contraction.
Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle) when applied as eye drops. It is also an effective cycloplegic agent in myopic children.
G-Protein Coupled Receptor Ligands; Muscarinic Acetylcholine Receptor Ligands
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SPECIFICATIONS
Catalog Number
T-120
Size
250 mg
Purity
>96%
Concentration
10 nM
Shipping Temp
Room Temperature
Molecular Weight
284.3 Da
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