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Troponin Complex, Cardiac (TnC, TnI, TnT, TNNC1, TNNT2, TNNI3)

Troponin Complex, Cardiac (TnC, TnI, TnT, TNNC1, TNNT2, TNNI3)

Cat no: T8665-11B

Supplier: United States Biological
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The three-unit troponin complex (Troponin I, T and C), bound to tropomyosin, is located on the actin filament of skeletal and cardiac muscle. Troponin T binds to tropomyosin to form the troponin-tropomyosin complex. Troponin C binds calcium ions to produce a conformational change in Troponin I. Troponin I binds to the actin in thin myofilaments to hold the troponin-tropomyosin complex in place. When calcium binds to troponin, a conformation change is forced in troponin and tropomyosin, moving both proteins away from the myosin binding sites on the actin filaments. Thus, myosin can bind to actin and muscle contraction occurs. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Hybridoma: Spleen cells from immunized BALB/c mice were fused with cells of the SP2/0 mouse myeloma cell line. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8665-11B
Reactivities: Human
Hosts: Mouse
Applications: ELISA
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Babuin, L. and Jaffe, A. S. (2005) Troponin: the biomarker of choice for the detection of cardiac injury. Can. Med. Assoc. J. 173: 1191-1202. 2. Gomes, A. V. et al. (2002) The role of troponins in muscle contraction. IUBMB Life. 54: 323-333.
Additional info: Recognizes human native troponin, a complex of three proteins integral to muscle contraction. It does not cross-react with any of the individual components Troponin I, T or C.

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