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Troponin I, Cardiac (cTnI) (Biotin)

Troponin I, Cardiac (cTnI) (Biotin)

Cat no: T8665-16E1

Supplier: United States Biological
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Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits, the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place, because of which myosin cannot bind to actin in relaxed muscle. When Calcium binds to the Troponin C it causes certain confomational changes which leads to dislocation of troponin I. The letter
Catalogue number: T8665-16E1
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Conjugates: Biotin
Size: 1mg
Form: Supplied as a liquid in PBS. No preservative added. Labeled with Biotin.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes free human cardiac troponin I (cTnl) and cTnl forming complexes with other troponin components. Not effected by heparin, phosphorylation and oxidation. Recognizes an epitope located between amino acid residues 83-93 of cTnI. No crossreactivity with skeletal muscle troponin I.

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