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Troponin I, Cardiac (cTnI)

Troponin I, Cardiac (cTnI)

Cat no: T8665-18A

Supplier: United States Biological
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Human cardiac-specific troponin I (TnI) is an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8665-18A
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Takeda, S. (2005) Crystal structure of troponin and the molecular mechanism of muscle regulation. J. Electron Microscopy 54 (supplement 1): i35-i41. 2. Jeremias, A. and Gibson, C.M. (2005) Narrative review: Alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann. Intern Med. 142: 786-791.
Additional info: Recognizes human cardiac-specific troponin I (TnI).

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