Home  >  Products  >  Troponin I, Cardiac, Human (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, Troponin-I, Troponin I Cardiac Muscle, TNNC 1, TNNC1, Troponin I Type 3 Cardiac, TNNI3)
Troponin I, Cardiac, Human (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, Troponin-I, Troponin I Cardiac Muscle, TNNC 1, TNNC1, Troponin I Type 3 Cardiac, TNNI3)

Troponin I, Cardiac, Human (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, Troponin-I, Troponin I Cardiac Muscle, TNNC 1, TNNC1, Troponin I Type 3 Cardiac, TNNI3)

Cat no: T8665-14M

Supplier: United States Biological
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In clinical studies of new drugs, new methods of surgery are carried out on experimental animals. The effects of the new technologies on cardiac function and on cardiac myocyte viability can be important. The majority of the anti-cardiac Troponin I MAbs have wide specificity and recognize not only human cardiac Troponin I but also cardiac Troponin I from other species. Several combinations of MAbs were tested and could be used for quantitative detection of cardiac Troponin I in blood of different species. An assay utilizing T8665-14M as a capture and T8665-15E as detection gives equal response with antigens from different animal species. Other MAb pairs, with epitopes located in different parts of troponin molecule, could also be used for the same purpose. Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: Predicted molecular weight 24kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8665-14M
Reactivities: Human, Mouse, Rat, Canine
Hosts: Mouse
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1
Purity: As reported
References: Sarko J & Pollack CV Cardiac troponins. J Emerg Med 23:57-65 (2002). Gomes AV et al. The role of troponins in muscle contraction. IUBMB Life 54:323-33 (2002). Hamm CW Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103 Suppl 1:S63-9 (2001). Labugger R et al. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 102:1221-6 (2000). Wu AH et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 44:1198-208 (1998). Katrukha AG et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 43:1379-85 (1997).
Additional info: This antibody is reacting with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components (In the presence of 5 mM EDTA). It is not affected by heparin, phosphorylation, oxidation and troponin complex formation. This antibody does not crossreact with skeletal muscle troponin I. Species Crossreactivity: Crossreacts with Mouse, Rat and canine. Expected to crossreact with Human due to sequence homology.

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