Troponin T, Cardiac (cTnT)

Troponin T is a thin filament regulatory protein of striated muscle that binds to troponin C and I and to tropomyosin and is required for calcium-dependent ATPase activity of myofibrillar proteins. It is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. This expression in the human heart is affected by heart failure.\n\nApplications: \nSuitable for use in ELISA, Immunoaffinity Purification and Western Blot. Other applications have not been tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nRecommended Pair:\nSuitable for use as the capture or solid phase antibody.\nMatched to T8665-22A, T8665-22B or T8665-30A as the detection or conjugate (label) antibody.\n\nHybridoma:\nHybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8665-22C

Size

1mg

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum, Bov, Ch/Bird

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human cardiac Troponin T. Recognizes an epitope between aa60-70. Does not crossreact with human skeletal Troponin T. Species Crossreactivity: Bovine and chicken. Does not react with canine, feline, fish, porcine, mouse, goat, rabbit or rat.