Troponin T, Cardiac (Troponin T Cardiac Muscle, TnTC, Troponin T Type 2 (Cardiac), Troponin T2, TNNT2, Cardiac Muscle Troponin T, cTnT, CMD1D, CMH2, MGC3889)

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations within the protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the gene undergo alternative splicing that results in many tissue-specific isoforms.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8665-23G

Size

200ug

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Can

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Sarko, J. & Pollack, C.V., Cardiac troponins. J Emerg Med 23:57-65 (2002). 2. Gomes, A.V. et al. IUBMB Life 54:323-33 (2002). 3. Hamm, C.W. Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103 Suppl 1:S63-9 (2001). 4. Labugger, R. et al. Circulation 102:1221-6 (2000). 5. Wu, A.H. et al. Clin Chem 44:1198-208 (1998). 6. Katrukha, A.G. et al. Clin Chem 43:1379-85 (1997).

Additional Info

Recognizes human cadiac troponin at ~35.4kD. Does not crossreact with skeletal muscle troponin T, cTnI and TnC. Species Crossreactivity: mouse, rat and canine.