Troponin T, Cardiac (Troponin T Cardiac Muscle, TnTC, Troponin T Type 2 (Cardiac), Troponin T2, TNNT2, Cardiac Muscle Troponin T, cTnT, CMD1D, CMH2, MGC3889)

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations within the protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the gene undergo alternative splicing that results in many tissue-specific isoforms.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

T8665-23H

Size

200ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum, Bov, Can, Goat, Rabbit

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Sarko J & Pollack CV Cardiac troponins. J Emerg Med 23:57-65 (2002). <PUBMED:12217473>\n2. Gomes AV et al. The role of troponins in muscle contraction. IUBMB Life 54:323-33 (2002). <PUBMED:12665242>\n3. Hamm CW Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103 Suppl 1:S63-9 (2001). <PUBMED:11567671>\n4. Labugger R et al. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 102:1221-6 (2000). <PUBMED:10982534>\n5. Wu AH et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 44:1198-208 (1998). <PUBMED:9625043>\n6. Katrukha AG et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 43:1379-85 (1997). <PUBMED:9267317>

Additional Info

Recognizes human cadiac troponin at ~35kD. Does not crossreact with skeletal muscle troponin T, cTnI or TnC. Species Crossreactivity: bovine, canine, goat, rabbit. Does not crossreact with mouse, rat, feline, fish or porcine.