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TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1, ANKTM1, Ankyrin-like with Transmembrane domains protein 1, Transformation-sensitive Protein p120)

TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1, ANKTM1, Ankyrin-like with Transmembrane domains protein 1, Transformation-sensitive Protein p120)

Cat no: T8666-12E

Supplier: United States Biological
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Transient receptor potential A1 (TRPA1) is an excitatory cation channel that is highly expressed in nociceptive neurons and plays an important role in inflammatory pain. TRPA1 mediates the response to the proalgesic bradykinin as well as to pungent irritants found in mustards, garlic, and cinnamon. TRPA1 may also be involved in hearing (as the mammalian hair cell mechanotransducer) and in the detection of cold stimuli. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin): 10-20ug/ml Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. 0.01M sodium citrate buffer, pH 6.0 is recommended for this purpose. Optimal dilutions to be determined by the researcher. Positive Control: Spinal cord, DRG Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8666-12E
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Story, G.M. and Gereau, R.W. 4th. (2006) Neuron. 50: 177-180.
Additional info: Recognizes human TRPA1.

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