The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains. It localizes in the 8q13 region of chromosome. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins.The function of TRPA1 may involve a role in signal transduction and growth control. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. TRPA1 associates with the tumor-suppressor protein CYLD and TRPA1 is a novel substrate for the de-ubiquitinating activity of CYLD. TRPA1 is expressed at very low level in Human fibroblasts and at a moderate level in liposarcoma cells.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 10-20ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Spinal cord, DRG
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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