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TRPC3, CT (Transient Receptor Potential Cation Channel, Subfamily C, Member 3, HTRP-3, HTRP3, TRP3)

TRPC3, CT (Transient Receptor Potential Cation Channel, Subfamily C, Member 3, HTRP-3, HTRP3, TRP3)

Cat no: T8666-14D

Supplier: United States Biological
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The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC- coupled recept ors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist- activated but not store-operated or directly receptor- activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Immunohistochemistry: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8666-14D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Contell C, et al (2002) Mol. Cell. 9:229-31. 2. Trebak M, et al (2003) Cell Calcium. 33:451-61. 3. Zitt C, et al (1997) J. Cell. Biol. 1333-41. 4. Dietrich A, et al (2005) Pflugers Arch. 451:72-80.
Additional info: Recognizes human TRPC3. Species Crossreactivity: mouse and rat.

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