Home  >  Products  >  TRPC6, NT (Transient Receptor Potential Cation Channel Subfamily C Member 6, TRP6, TRP-6, TRPC 6, TRRP6, bZ1P14.9, FLJ11098, FLJ14863, FSGS2, HGNC:12338, MTRP6, Short Transient Receptor Potential Channel 6, Transient Receptor Protein 6)
TRPC6, NT (Transient Receptor Potential Cation Channel Subfamily C Member 6, TRP6, TRP-6, TRPC 6, TRRP6, bZ1P14.9, FLJ11098, FLJ14863, FSGS2, HGNC:12338, MTRP6, Short Transient Receptor Potential Channel 6, Transient Receptor Protein 6)

TRPC6, NT (Transient Receptor Potential Cation Channel Subfamily C Member 6, TRP6, TRP-6, TRPC 6, TRRP6, bZ1P14.9, FLJ11098, FLJ14863, FSGS2, HGNC:12338, MTRP6, Short Transient Receptor Potential Channel 6, Transient Receptor Protein 6)

Cat no: T8666-30J

Supplier: United States Biological
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The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC- coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Immunohistochemistry: 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: K562 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8666-30J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Contell C, et al (2002) Mol. Cell. 9:229-31. 2. Dietrich A, et al (2005) Pflugers Arch. 451:72-80. 3. Trebak M, et al (2003) Cell Calcium. 33:451-61.
Additional info: Recognizes human TRPC6. Species Crossreactivity: mouse.

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