Home  >  Products  >  Tryptophan Hydroxylase 2, phosphorylated (Ser19) (Tryptophan 5-hydroxylase 2, TPH 2, TPH2, FLJ37295, HGNC:20692, Neuronal Tryptophan Hydroxylase, NTPH, Tryptophan 5-monooxygenase 2)
Tryptophan Hydroxylase 2, phosphorylated (Ser19) (Tryptophan 5-hydroxylase 2, TPH 2, TPH2, FLJ37295, HGNC:20692, Neuronal Tryptophan Hydroxylase, NTPH, Tryptophan 5-monooxygenase 2)

Tryptophan Hydroxylase 2, phosphorylated (Ser19) (Tryptophan 5-hydroxylase 2, TPH 2, TPH2, FLJ37295, HGNC:20692, Neuronal Tryptophan Hydroxylase, NTPH, Tryptophan 5-monooxygenase 2)

Cat no: T9014-84A

Supplier: United States Biological
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Tryptophan Hydroxylase (TPH) is a rate-limiting enzyme which catalyses the 5-hydroxylation of tryptophan, to form the amino acid 5-hydroxytryptophan (5-HTP), in the first stage of the biosynthesis of the neurotransmitter serotonin (5-hydroxytryptamine/5HT). Mammalian TPH is encoded by two genes: TPH1 expressed in peripheral tissues e.g. skin and gut, and TPH2 primarily expressed in the brain. Studies have demonstrated the regulation/enhancement of TPH activity through phosphorylation by cAMP?dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaMKII), the latter of which phosphorylates a Ser19 site within the regulatory domain of TPH2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T9014-84A
Reactivities: Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM Hepes, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. McKinney, J. et al. (2005) Different properties of the central and peripheral forms of human tryptophan hydroxylase. J. Neurochem. 92: 311-320
Additional info: Recognizes rat Tryptophan Hydroxylase 2 (TPH2) protein, when phosphorylated at Ser19. Species sequence homology: Bovine, Zebrafish, Mouse.

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