Home  >  Products  >  Tryptophan Hydroxylase (TPH, TPRH, MGC119994, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase, Tryptophan 5-monooxygenase 1, Tryptophan Hydroxylase 1, TPH 1, TPH1)
Tryptophan Hydroxylase (TPH, TPRH, MGC119994, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase, Tryptophan 5-monooxygenase 1, Tryptophan Hydroxylase 1, TPH 1, TPH1)

Tryptophan Hydroxylase (TPH, TPRH, MGC119994, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase, Tryptophan 5-monooxygenase 1, Tryptophan Hydroxylase 1, TPH 1, TPH1)

Cat no: T9014-82A

Supplier: United States Biological
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Tryptophan hydroxylase (TPH) is one of a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. It contains catalytic and regulatory domains, as well as a short tetramerization domain. TPH is the first catalytic step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland. TPH plays an important role in the pathology of several neuropsychiatric disorders, including depression, aggression, and schizophrenia. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Western Blot: 1:1,000. A 55kD band should be detected. Immunohistochemistry: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T9014-82A
Reactivities: Rat
Hosts: Sheep
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: As reported
P type: Pab
Purity: As reported
References: 1. Haycock, J.W., et al. A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope. J. Neurosci. Methods. 114(2):205-12, 2002.
Additional info: Specific for tryptophan hydroxylase. Species Crossreactivity: This antibody reacts with rat. It should crossreact with other mammalian species.

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