Tryptophan Hydroxylase (TPH, TPRH, TRPH, ADHD7, NTPH )

Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). Tryptophan hydroxylase\\atalyzes the biopterin-dependent monooxygenation of tryptophan to5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Human tryptophan hydroxylase (TPH) is mapped to chromosome 11p15.3-p14 by in situ hybridization. \n\nUniProt Number:\nHuman(P17752), Mouse(P17532), Rat(P09810), Human(Q8IWU9), Mouse(Q8CGV2), Rat(Q8CGU9)\n\nGene ID:\nTPH1; TPH2\n\nApplications:\nSuitable for use in Western Blot.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

145333

Size

100ug

Applications

WB

Hosts

Mouse

Reactivities

Hum, Rat, Rabbit

Form

Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

P Type

Mab

Isotype

IgG3

References

1. Craig, S. P.; Boularand, S.; Darmon, M. C.; Mallet, J.; Craig, I. W. : Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3-p14 by in situ hybridization. Cytogenet. Cell Genet. 56: 157-159, 1991.\n2. Nielsen, D. A.; Dean, M.; Goldman, D. : Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am. J. Hum. Genet. 51: 1366-1371, 1992.

Additional Info

Recognizes human, rat and rabbit Tryptophan Hydroxylase. No crossreactivity with other proteins.