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TSLP (Thymic Stromal Lymphopoietin)

TSLP (Thymic Stromal Lymphopoietin)

Cat no: T9127-03

Supplier: United States Biological
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Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. Despite its predicted molecular weight, TSLP often migrates at a higher molecular weight in SDS-PAGE. At least two differentially spliced isoforms of TSLP are known to exist. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: 2.5ug/ml Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A20 Cell Lysate (WB), Human Brain Tissue (IHC) Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T9127-03
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ziegler SF and Liu Y-J. Nature Immunol. 2006; 7:709-14. 2. Sims JE, Williams DE, Morrissey PJ, et al. J. Exp. Med. 2000; 192:671-80. 3. Levin SD, Koelling RM, Friend SL, et al. J. Immunol. 1999; 162:677-83. 4. Quentmeier H, Drexler HG, Fleckenstein D, et al. Leukemia 2001; 15:1286-92.
Additional info: Recognizes human TSLP. Species Crossreactivity: mouse.

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