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Tsp23 (Transcript Similar p23)

Tsp23 (Transcript Similar p23)

Cat no: T8264-68

Supplier: United States Biological
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p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25kD) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate
Catalogue number: T8264-68
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Johnson J.L., Beito T. G., Krco C.J., Toft D.O. (1994) Mol Cell Biol 14: 1956-63, 2. Weikl T., Abelmann K., Buchner J. (1999) J Mol Biol 293: 685-91, 3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A., Toft D.O. (2000) J Biol Chem 275: 23045-52, 4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50, 5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70, 6. Holt S.E., et al. (1999) Genes Dev 13: 817-26, 7. Hu J., Toft D., Anselmo D., Wang X. (2002) J Virol 76: 269-79, 8. Felts, S.J., Toft D.O. (2003) Cell Stress Chaperones. 8: 108- 13, 9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia, 10. Freeman B.C., Felts S.J., Toft D.O., Yamamato K.R. (2000) Genes Dev. 14(4): 433-434.
Additional info: Recognizes human Tsp23 at ~19kD. Does not react with p23.

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