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TTC8 (Tetratricopeptide Repeat Protein 8, TPR Repeat Protein 8, Bardet-Biedl Syndrome 8 Protein, BBS8)

TTC8 (Tetratricopeptide Repeat Protein 8, TPR Repeat Protein 8, Bardet-Biedl Syndrome 8 Protein, BBS8)

Cat no: T3503-28A

Supplier: United States Biological
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The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 0.2-0.6ug/ml, human testis lysates observed on ~60kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T3503-28A
Reactivities: Human, Mouse, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Bin J, Madhavan J, Ferrini W, Mok CA, Billingsley G, Héon E, BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population. Human mutation 2009 Jul 30(7):E737-46.
Additional info: Recognizes human TTC8. Species sequence homology: Bovine, canine, mouse and porcine.

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