TTR pAb

Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermed-iate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein).

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SPECIFICATIONS

Catalog Number

BS6039

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human TTR.

Species

TTR pAb detects endogenous levels of TTR protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P02766

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 16 kDa

Alternative Names

Amyloid polyneuropathy; \nAmyloidosis I; \nATTR; \nCarpal tunnel syndrome 1; \nCTS; \nCTS1; \nDysprealbuminemic euthyroidal hyperthyroxinemia; \nDystransthyretinemic hyperthyroxinemia; \nHsT2651; \nPALB; \nPrealbumin amyloidosis type I; \nPrealbumin; \nSenile systemic amyloidosis; \nTBPA; \nThyroxine binding prealbumin; \nTransthyretin; \nTTHY; \nTTR; \nTTR protein; \n