Tumor Necrosis Factor alpha, Recombinant, Human (TNFa, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFSF2)

Supplier:

United States Biological

Cat no: T9160-10K

Tumor Necrosis Factor alpha, Recombinant, Human (TNFa, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFSF2)

Tumor necrosis factor-a (TNF-a) is a pleiotropic pro-inflammatory cytokine produced mainly by activated macrophages and in smaller amounts by several other types of cell. TNF-a has been isolated and characterized from a large number of mammals and fish species. TNF-a is expressed in two different forms: a soluble. Mature 17kD form and a transmembrane 26kD form. TNF-a interacts with two distinct cell-surface receptors : Tumor necrosis factor receptor 1(TNFR1) and TNFR2. these mediate the cellular actions. The actions of TNF-a are diverse and profound involving inflammation, apoptosis, cell proliferation and the stimulation of various aspects within the immune system. TNF-a is increasingly recognized as a key regulator of lipid metabolism in adipose tissue and protein catabolism in muscle and in disease states such as cancer, Acquired Immune Deficiency Syndrome (AIDS) and obesity-related insulin resistance.\n\nSource:\nRecombinant corresponding to aa77-23, from human TNF-a, expressed in E.coli.\n\nMolecular Weight:\n~17.5kD\n\nEndotoxin Level:\n(same/less than)0.05EU/ug\n\nSpecific Activity: \nThe ED50 as determined by the cytolysis of murine L929cells in the presense of actinomycin D is 0.03-0.06 ng/ml.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T9160-10K

Size

20ug

Form

Supplied as a liquid in 20mM Tris, pH 8.0, 1mM EDTA, 10% glycerol.

Purity

~98% (SDS-PAGE)

References

1. Wen-Xing Ding et al (2004) J.Cell. Mol. Med 8(4);445-454. 2. Sudhir Gupta (2002) Journal of Clinical Immunology 22(4);185-194. 3. Frederick W. goetz et al (2004) Developmental and comparative Immunology 28;487-497. 4. Havell, E.A. (1987) J. Immunol. 39:4225-4231.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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