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Tumor Necrosis Factor alpha, Recombinant, Human (TNFa)

Cat no: T9160-10F

Tumor Necrosis Factor alpha, Recombinant, Human (TNFa)

Tumor necrosis factor alpha (TNF-a), also called cachectin, is produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes endothelial cells, smooth muscle cells and some transformed cells. TNF-a occurs as a secreted, soluble form and as a membrane-anchored form, both of which are biologically active. The naturally-occurring form of TNF-a is glycosylated, but non-glycosylated recombinant TNF-a has comparable biological activity. The biologically active native form of TNF-a is reportedly a trimer. Human and murine TNF-a show approximately 79% homology at the amino acid level and crossreactivity between the two species. Two types of receptors for TNF-a have been described and virtually all cell types studied show the presence of one or both of these receptor types.\n\nBiological Activity: \nFully biologically active when compared to standard. The Specific Activity is (same/more than)2.0

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SPECIFICATIONS

Catalog Number

T9160-10F

Size

10ug

Form

Supplied as a lyophilized powder in PBS, pH 7.5. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1mg/ml.

Purity

~95% by SDS-PAGE and HPLC analyses.

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